Research groups within the Institute of Molecular Biology and Biophysics study molecular structure and function of biological molecules using a combination of biochemistry, molecular biology and structural biology methods including NMR, crystallography and Electron Microscopy.  We investigate DNA and RNA complexes with proteins and large cellular assemblies involved in the expression of genetic information, the mechanisms of protein folding and assembly as well as cellular machines responsible for protein degradation. We also study how membrane proteins catalyse transport across membranes and the function of assemblies involved in cell to cell interactions. Mechanistic studies are also complemented with research aimed at methods development in structural biology.